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PostPosted: Wed Mar 26, 2014 3:22 am    Post subject: East river. Ten years later Reply with quote

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PostPosted: Wed Mar 26, 2014 11:15 am    Post subject: according to the introduction. Reply with quote

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PostPosted: Thu Apr 03, 2014 4:54 pm    Post subject: the other children in the kindergarten Reply with quote

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PostPosted: Fri May 02, 2014 3:11 am    Post subject: .View this table Reply with quote

visit variability in blood pressure with cognitive function in old age
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Furthermore,[url=http://www.eluer.com/colorbox/tnrequinenfant.php]tn requin enfant[/url], higher variability in both systolic and diastolic blood pressure was associated with lower hippocampal volume and cortical infarcts, and higher variability in diastolic blood pressure was associated with cerebral microbleeds (all PConclusion Higher visit to visit variability in blood pressure independent of average blood pressure was associated with impaired cognitive function in old age.IntroductionVisit to visit variability in blood pressure independent of average blood pressure is related to cerebrovascular damage.1 It has been shown that higher blood pressure variability increases the risk of stroke and that antihypertensives, which decrease both variability in blood pressure and mean blood pressure, more effectively reduce the risk of stroke.2 In addition, observational studies have shown associations of variability in blood pressure, independent of average blood pressure, with white matter hyperintensities,[url=http://www.pricelookup.net/cgi-bin/niketnrequinpascher.php]nike tn requin pas cher[/url], carotid artery intima media thickness,[url=http://www.invoicingtemplates.com/niketnenfant.php]nike tn enfant.php[/url], and atherosclerosis in older people (55 years).3 4 5The relation between increased variability in blood pressure and end organ damage is well established.6 Recent evidence indicates that higher visit to visit variability is linked with microvascular damage, endothelial injury, and disturbances in vascular smooth muscle functioning.7 8 Indicators of cerebral small vessel disease, including white matter hyperintensities, cortical microinfarcts, and cerebral microbleeds are implicated in the pathogenesis of cognitive impairment.9 10 11 Several pathological, observational, and experimental studies have shown that disruption of the blood brain barrier due to microvascular damage results in neuronal injury and accelerates neuronal loss and brain atrophy.12 Hence higher variability in blood pressure might potentially lead to cognitive impairment through changes in the brain structures and development of cerebral small vessel disease.We investigated the association of variability in blood pressure between visits independent of average blood pressure with cognitive function in older participants (>70 years) at high risk of cardiovascular disease. Additionally, we investigated possible explanations behind this association in a magnetic resonance imaging substudy.MethodsStudy design and participantsThe data in this study were obtained from PROSPER (The PROspective Study of Pravastatin in the Elderly at Risk), a randomised, double blind, placebo controlled trial designed to investigate the effect of pravastatin in the prevention of vascular events in elderly people with pre existing, or risk factors for, cardiovascular disease. This trial included 5804 people aged 70 82 years who were enrolled from three collaborating centres in Ireland, Scotland, and the Netherlands. Approximately 50% of the participants showed evidence of cardiovascular disease, including stable angina, intermittent claudication, stroke (the type, haemorrhagic or ischaemic, was unknown), transient ischaemic attack, myocardial infarction, and vascular surgery. The rest of the participants had one or more major cardiovascular risk factors, defined as hypertension,[url=http://www.iwjewelry.com/large_Italian_charm_images/chaussuresrequin.php]chaussures requin[/url], cigarette smoking,[url=http://www.nicholssoftware.com/Applications/niketnrequinpascher.php]nike tn requin pas cher[/url], or diabetes mellitus. The primary outcome of the study was the combined endpoint of definite or suspected death from coronary heart disease, non fatal myocardial infarction, and fatal or non fatal stroke during a mean follow up of 3.2 years. In the present study we included 5461 participants for whom data on variability in blood pressure and cognitive function were available. Additionally, participants from the Netherlands were invited to participate in a magnetic resonance imaging substudy. Participants were included from both the pravastatin and the placebo groups as we previously reported that treatment with pravastatin did not influence cognitive function, structural brain volumes, or indicators of cerebral small vessel disease.13 14 15Blood pressure measurementsWe measured systolic and diastolic blood pressure at baseline and every three months. Blood pressure was measured with participants in the sitting position and using a fully automatic electronic sphygmomanometer (Omron M4, Kyoto, Japan). All measurements were performed in the same clinical setting. In the analyses we used the average values of these blood pressure measurements. We defined visit to visit variability in blood pressure as the standard deviation of blood pressure measurements during the study period. We report the variability in blood pressure using only the standard deviation. Variance and coefficient of variation, which are two other measures of variability, are strongly correlated with the standard deviation (see supplementary table S 1) and they showed similar associations with cognitive and magnetic resonance imaging outcomes (data not shown).Cognitive functionThe mini mental state examination was used to evaluate global cognitive function at baseline; to exclude participants with poor cognitive function at baseline we used a cut off score of 24 points or more (out of 30) as an inclusion criterion. In the present study we used data on cognitive function assessed at the end of the study, after a mean follow up of 3.2 years, by a cognitive test battery consisting of four different tests. The Stroop colour and word test was used to assess selective attention and reaction time. The participants were asked to read the name of a colour, which appeared in a colour different from that being named. The outcome variable was the total number of seconds to complete the test; a higher score indicating worse performance. General cognitive speed was tested by the letter digit coding test. The participants had to match certain digits with letters according to a provided key. The outcome variable was the total number of correct entries in 60 seconds, with higher scores indicating better performance. The picture word learning test was used to assess immediate and delayed memory. The participants were shown 15 pictures and were then asked to recall as many pictures as possible in three trials. After 20 minutes they were asked to repeat the test to measure their delayed recall. The outcome variable was the accumulated number of correct recalled pictures, immediately and after 20 minutes,[url=http://www.creation-site-boutique.fr/jordan-enfant/]jordan enfant[/url], with higher scores indicating better performance. Detailed descriptions of the cognitive tests and the procedures have been published previously.16Magnetic resonance imaging substudyOverall, 646 of the 1100 Dutch participants in the PROSPER study consented to participate in the magnetic resonance imaging substudy. Forty of the 646 original study participants died during the follow up period. Magnetic resonance imaging was performed at the end of the follow up period in the remaining 606 participants. Data on visit to visit variability in blood pressure and magnetic resonance imaging were available for 553 participants. Details of individual variables of magnetic resonance imaging scanning have been published previously.13All imaging was performed on a magnetic resonance system operating at a field strength of 1.5 Tesla (Philips Medical Systems,[url=http://www.julie.daneman.org/wp-content/chaussurerequintnpascher.php]chaussure requin tn pas cher[/url], Best,[url=http://www.vaporeco.net/tbc258_Edit/basketrequin.php]basket requin[/url], Netherlands). We used the SIENAX technique to calculate grey and white matter volumes. In short, SIENAX starts by extracting brain and skull images from input data for the whole head. The brain image is then afne registered to Montreal Neurological Institute 152 space (by using the skull image to determine the registration scaling), done primarily to obtain the volumetric scaling factor to be used as normalisation for head size. Next we carried out tissue type segmentation with partial volume estimation to calculate the total volume of brain tissue (including separate estimates of volumes of grey matter,[url=http://www.srisaisamsthan.org/bootstrap3.0.3/tnpascher.php]tn pas cher[/url], white matter, peripheral grey matter, and ventricular cerebrospinal uid).17 The algorithm FIRST (the Oxford Centre for Functional MRI of the Brain's (FMRIB) integrated registration and segmentation tool) was applied to estimate the volume of hippocampus. In addition, we estimated the volume of six other subcortical regions, including nucleus accumbens, globus pallidus, amygdala, putamen, caudate nucleus, and thalamus. FIRST is part of FSL (FMRIB's software library) and performs both registration and segmentation of the mentioned subcortical regions.18 To assess cerebral microbleeds,[url=http://www.creation-site-boutique.fr/basket-jordan/]basket jordan[/url], two experienced raters blinded to the participants' clinical history read all the magnetic resonance imaging scans in consensus. Cerebral microbleeds were defined as focal areas of signal loss on T2 weighted gradient echo pulse sequence ("blooming effect") that were invisible or smaller on T2 weighted magnetic resonance imaging.19. For each participant we recorded the number and location (cortical, subcortical, and infratentorial) of the cerebral microbleeds. Segmentation of white matter hyperintensities volume was performed automatically using software for Neuro Image Processing in Experimental Research (SNIPER), an in house developed program for image processing.20 This segmentation was based on the T2 weighted and fluid attenuated inversion recovery (FLAIR) images. Cerebral infarcts were defined as parenchymal defects seen on FLAIR images with the same signal intensity as cerebrospinal fluid and a surrounding rim of high signal intensity after a vascular distribution.Personal and clinical characteristicsWe recorded the personal, medical, and anthropometric data of the participants at baseline. A fasting venous blood sample was taken for biochemical and haematological assessment. Western blotting was used on the plasma samples to determine apolipoprotein E epsilon 2/3/4 phenotype.21Statistical analysisCharacteristics of the study participants are reported as mean (standard deviation) for continuous variables and frequency (percentage) for categorical variables. We used Pearson's correlation coefficient to calculate the correlation between variability in blood pressure and average blood pressure. Linear regression models were used to assess the association of variability in blood pressure and average blood pressure with cognitive function. Dependent variables were the mean scores of the cognitive tests. In the tables these scores are presented in thirds of systolic and diastolic blood pressure and blood pressure variability. In the magnetic resonance imaging substudy, we used logistic regression models to estimate the odds ratio and 95% confidence interval of the presence of microbleeds or infarcts in different thirds of blood pressure variability as well as average blood pressure. We used multivariable linear regression models to test the association between blood pressure variability and average blood pressure with volume of white matter hyperintensities and structural brain volumes. P values in all analyses were calculated using systolic and diastolic blood pressure variability as continuous variables.We performed our analyses in three steps. In the first step, we carried out crude analyses, in which we only adjusted for cognitive test version where appropriate. In the second step, we added age, sex, education, and country as covariates to investigate the potential influence of these factors on the associations (model 1). In the final model (model 2), we further adjusted the analyses for the following potential confounders: cardiovascular diseases and risk factors (history of vascular disease, history of hypertension, history of diabetes mellitus,[url=http://www.nenshtrim.org/wp-includes/nikerequintnpascher.php]nike requin tn pas cher[/url], smoking status, cholesterol levels, body mass index), average blood pressure, statin treatment, and apolipoprotein E genotype. We adjusted the analyses of systolic blood pressure variability with cognitive function and magnetic resonance imaging outcomes for average systolic blood pressure. The analyses of variability in diastolic blood pressure with cognitive function and magnetic resonance imaging outcomes were adjusted for average diastolic blood pressure. Since the associations did not essentially change in different models, results of the second model are presented in the manuscript and results from the other models are presented in the supplementary file (tables S 2 and S 3). All analyses were performed using SPSS software (version 20.0.0).ResultsTable 1 shows the characteristics of the participants in the whole group and in the magnetic resonance imaging substudy. Blood pressure was measured in an average number of 12.7 visits in the whole group and 12.9 visits in the magnetic resonance imaging substudy. Average systolic and diastolic blood pressure over the period of blood pressure measurements were 153.1 mm Hg and 82.5 mm Hg, respectively. The corresponding mean standard deviation values during this period were 14.8 mm Hg and 7.1 mm Hg.View this table:View PopupView InlineTable 1 Characteristics of study participants in whole group and magnetic resonance imaging (MRI) substudy. Values are means (standard deviations) unless stated otherwiseThere was a weak but significant correlation between average systolic blood pressure and standard deviation of systolic blood pressure measurements (r=0.20, PTable 2 shows the association of visit to visit variability in systolic and diastolic blood pressure with cognitive function. Higher variability was associated with worse performance on the Stroop test (both P presents the mean cognitive scores (95% confidence intervals) in each third of systolic and diastolic blood pressure variability. Data on the association of blood pressure variability with cognitive function from crude and minimally adjusted models are shown in the supplementary file (tables S 2 and S 3). Furthermore, we found a significant association of higher average systolic and diastolic blood pressure with worse performance in different domains of cognitive function (all P0.05) (see supplementary table S 4).View this table:View PopupView InlineTable 2 Cognitive function in thirds of visit to visit blood pressure variability. Values are means (standard errors) unless stated otherwiseView larger version:In a new windowDownload as PowerPoint SlideTable 3 shows the association of visit to visit variability in systolic and diastolic blood pressure with structural brain volumes. Higher variability was associated with lower hippocampal volume (both P=0.01). There was no association between blood pressure variability and volume of the other brain structures (all P>0.05), except for the association between higher variability in systolic blood pressure and lower amygdala and putamen volumes (both P=0.04). Analyses were adjusted for average systolic and diastolic blood pressures, which themselves were not associated with structural brain volumes (all P>0.05) (see supplementary table S 5).相关的主题文章:


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Wants to be a Millionaire?" among her accomplishments. "Although I enjoyed the patents with which I worked, the actual practice of being a litigator was rather boring, so I left it behind to do something a little more fun and a lot more rewarding," she wrote of her career switch.
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PostPosted: Fri May 02, 2014 3:12 am    Post subject: .View this table Reply with quote

visit variability in blood pressure with cognitive function in old age
AbstractObjective To investigate the association between visit to visit variability in blood pressure and cognitive function in old age (>70 years).Setting PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) study,[url=http://www.adjusteragency.com/vClientCase_Client/basketrequinpascher.php]basket requin pas cher[/url], a collaboration between centres in Ireland, Scotland, and the Netherlands.Participants 5461 participants, mean age 75.3 years, who were at risk of cardiovascular disease. Blood pressure was measured every three months during an average of 3.2 years. Furthermore,[url=http://www.eluer.com/colorbox/tnrequinenfant.php]tn requin enfant[/url], higher variability in both systolic and diastolic blood pressure was associated with lower hippocampal volume and cortical infarcts, and higher variability in diastolic blood pressure was associated with cerebral microbleeds (all PConclusion Higher visit to visit variability in blood pressure independent of average blood pressure was associated with impaired cognitive function in old age.IntroductionVisit to visit variability in blood pressure independent of average blood pressure is related to cerebrovascular damage.1 It has been shown that higher blood pressure variability increases the risk of stroke and that antihypertensives, which decrease both variability in blood pressure and mean blood pressure, more effectively reduce the risk of stroke.2 In addition, observational studies have shown associations of variability in blood pressure, independent of average blood pressure, with white matter hyperintensities,[url=http://www.pricelookup.net/cgi-bin/niketnrequinpascher.php]nike tn requin pas cher[/url], carotid artery intima media thickness,[url=http://www.invoicingtemplates.com/niketnenfant.php]nike tn enfant.php[/url], and atherosclerosis in older people (55 years).3 4 5The relation between increased variability in blood pressure and end organ damage is well established.6 Recent evidence indicates that higher visit to visit variability is linked with microvascular damage, endothelial injury, and disturbances in vascular smooth muscle functioning.7 8 Indicators of cerebral small vessel disease, including white matter hyperintensities, cortical microinfarcts, and cerebral microbleeds are implicated in the pathogenesis of cognitive impairment.9 10 11 Several pathological, observational, and experimental studies have shown that disruption of the blood brain barrier due to microvascular damage results in neuronal injury and accelerates neuronal loss and brain atrophy.12 Hence higher variability in blood pressure might potentially lead to cognitive impairment through changes in the brain structures and development of cerebral small vessel disease.We investigated the association of variability in blood pressure between visits independent of average blood pressure with cognitive function in older participants (>70 years) at high risk of cardiovascular disease. Additionally, we investigated possible explanations behind this association in a magnetic resonance imaging substudy.MethodsStudy design and participantsThe data in this study were obtained from PROSPER (The PROspective Study of Pravastatin in the Elderly at Risk), a randomised, double blind, placebo controlled trial designed to investigate the effect of pravastatin in the prevention of vascular events in elderly people with pre existing, or risk factors for, cardiovascular disease. This trial included 5804 people aged 70 82 years who were enrolled from three collaborating centres in Ireland, Scotland, and the Netherlands. Approximately 50% of the participants showed evidence of cardiovascular disease, including stable angina, intermittent claudication, stroke (the type, haemorrhagic or ischaemic, was unknown), transient ischaemic attack, myocardial infarction, and vascular surgery. The rest of the participants had one or more major cardiovascular risk factors, defined as hypertension,[url=http://www.iwjewelry.com/large_Italian_charm_images/chaussuresrequin.php]chaussures requin[/url], cigarette smoking,[url=http://www.nicholssoftware.com/Applications/niketnrequinpascher.php]nike tn requin pas cher[/url], or diabetes mellitus. The primary outcome of the study was the combined endpoint of definite or suspected death from coronary heart disease, non fatal myocardial infarction, and fatal or non fatal stroke during a mean follow up of 3.2 years. In the present study we included 5461 participants for whom data on variability in blood pressure and cognitive function were available. Additionally, participants from the Netherlands were invited to participate in a magnetic resonance imaging substudy. Participants were included from both the pravastatin and the placebo groups as we previously reported that treatment with pravastatin did not influence cognitive function, structural brain volumes, or indicators of cerebral small vessel disease.13 14 15Blood pressure measurementsWe measured systolic and diastolic blood pressure at baseline and every three months. Blood pressure was measured with participants in the sitting position and using a fully automatic electronic sphygmomanometer (Omron M4, Kyoto, Japan). All measurements were performed in the same clinical setting. In the analyses we used the average values of these blood pressure measurements. We defined visit to visit variability in blood pressure as the standard deviation of blood pressure measurements during the study period. We report the variability in blood pressure using only the standard deviation. Variance and coefficient of variation, which are two other measures of variability, are strongly correlated with the standard deviation (see supplementary table S 1) and they showed similar associations with cognitive and magnetic resonance imaging outcomes (data not shown).Cognitive functionThe mini mental state examination was used to evaluate global cognitive function at baseline; to exclude participants with poor cognitive function at baseline we used a cut off score of 24 points or more (out of 30) as an inclusion criterion. In the present study we used data on cognitive function assessed at the end of the study, after a mean follow up of 3.2 years, by a cognitive test battery consisting of four different tests. The Stroop colour and word test was used to assess selective attention and reaction time. The participants were asked to read the name of a colour, which appeared in a colour different from that being named. The outcome variable was the total number of seconds to complete the test; a higher score indicating worse performance. General cognitive speed was tested by the letter digit coding test. The participants had to match certain digits with letters according to a provided key. The outcome variable was the total number of correct entries in 60 seconds, with higher scores indicating better performance. The picture word learning test was used to assess immediate and delayed memory. The participants were shown 15 pictures and were then asked to recall as many pictures as possible in three trials. After 20 minutes they were asked to repeat the test to measure their delayed recall. The outcome variable was the accumulated number of correct recalled pictures, immediately and after 20 minutes,[url=http://www.creation-site-boutique.fr/jordan-enfant/]jordan enfant[/url], with higher scores indicating better performance. Detailed descriptions of the cognitive tests and the procedures have been published previously.16Magnetic resonance imaging substudyOverall, 646 of the 1100 Dutch participants in the PROSPER study consented to participate in the magnetic resonance imaging substudy. Forty of the 646 original study participants died during the follow up period. Magnetic resonance imaging was performed at the end of the follow up period in the remaining 606 participants. Data on visit to visit variability in blood pressure and magnetic resonance imaging were available for 553 participants. Details of individual variables of magnetic resonance imaging scanning have been published previously.13All imaging was performed on a magnetic resonance system operating at a field strength of 1.5 Tesla (Philips Medical Systems,[url=http://www.julie.daneman.org/wp-content/chaussurerequintnpascher.php]chaussure requin tn pas cher[/url], Best,[url=http://www.vaporeco.net/tbc258_Edit/basketrequin.php]basket requin[/url], Netherlands). We used the SIENAX technique to calculate grey and white matter volumes. In short, SIENAX starts by extracting brain and skull images from input data for the whole head. The brain image is then afne registered to Montreal Neurological Institute 152 space (by using the skull image to determine the registration scaling), done primarily to obtain the volumetric scaling factor to be used as normalisation for head size. Next we carried out tissue type segmentation with partial volume estimation to calculate the total volume of brain tissue (including separate estimates of volumes of grey matter,[url=http://www.srisaisamsthan.org/bootstrap3.0.3/tnpascher.php]tn pas cher[/url], white matter, peripheral grey matter, and ventricular cerebrospinal uid).17 The algorithm FIRST (the Oxford Centre for Functional MRI of the Brain's (FMRIB) integrated registration and segmentation tool) was applied to estimate the volume of hippocampus. In addition, we estimated the volume of six other subcortical regions, including nucleus accumbens, globus pallidus, amygdala, putamen, caudate nucleus, and thalamus. FIRST is part of FSL (FMRIB's software library) and performs both registration and segmentation of the mentioned subcortical regions.18 To assess cerebral microbleeds,[url=http://www.creation-site-boutique.fr/basket-jordan/]basket jordan[/url], two experienced raters blinded to the participants' clinical history read all the magnetic resonance imaging scans in consensus. Cerebral microbleeds were defined as focal areas of signal loss on T2 weighted gradient echo pulse sequence ("blooming effect") that were invisible or smaller on T2 weighted magnetic resonance imaging.19. For each participant we recorded the number and location (cortical, subcortical, and infratentorial) of the cerebral microbleeds. Segmentation of white matter hyperintensities volume was performed automatically using software for Neuro Image Processing in Experimental Research (SNIPER), an in house developed program for image processing.20 This segmentation was based on the T2 weighted and fluid attenuated inversion recovery (FLAIR) images. Cerebral infarcts were defined as parenchymal defects seen on FLAIR images with the same signal intensity as cerebrospinal fluid and a surrounding rim of high signal intensity after a vascular distribution.Personal and clinical characteristicsWe recorded the personal, medical, and anthropometric data of the participants at baseline. A fasting venous blood sample was taken for biochemical and haematological assessment. Western blotting was used on the plasma samples to determine apolipoprotein E epsilon 2/3/4 phenotype.21Statistical analysisCharacteristics of the study participants are reported as mean (standard deviation) for continuous variables and frequency (percentage) for categorical variables. We used Pearson's correlation coefficient to calculate the correlation between variability in blood pressure and average blood pressure. Linear regression models were used to assess the association of variability in blood pressure and average blood pressure with cognitive function. Dependent variables were the mean scores of the cognitive tests. In the tables these scores are presented in thirds of systolic and diastolic blood pressure and blood pressure variability. In the magnetic resonance imaging substudy, we used logistic regression models to estimate the odds ratio and 95% confidence interval of the presence of microbleeds or infarcts in different thirds of blood pressure variability as well as average blood pressure. We used multivariable linear regression models to test the association between blood pressure variability and average blood pressure with volume of white matter hyperintensities and structural brain volumes. P values in all analyses were calculated using systolic and diastolic blood pressure variability as continuous variables.We performed our analyses in three steps. In the first step, we carried out crude analyses, in which we only adjusted for cognitive test version where appropriate. In the second step, we added age, sex, education, and country as covariates to investigate the potential influence of these factors on the associations (model 1). In the final model (model 2), we further adjusted the analyses for the following potential confounders: cardiovascular diseases and risk factors (history of vascular disease, history of hypertension, history of diabetes mellitus,[url=http://www.nenshtrim.org/wp-includes/nikerequintnpascher.php]nike requin tn pas cher[/url], smoking status, cholesterol levels, body mass index), average blood pressure, statin treatment, and apolipoprotein E genotype. We adjusted the analyses of systolic blood pressure variability with cognitive function and magnetic resonance imaging outcomes for average systolic blood pressure. The analyses of variability in diastolic blood pressure with cognitive function and magnetic resonance imaging outcomes were adjusted for average diastolic blood pressure. Since the associations did not essentially change in different models, results of the second model are presented in the manuscript and results from the other models are presented in the supplementary file (tables S 2 and S 3). All analyses were performed using SPSS software (version 20.0.0).ResultsTable 1 shows the characteristics of the participants in the whole group and in the magnetic resonance imaging substudy. Blood pressure was measured in an average number of 12.7 visits in the whole group and 12.9 visits in the magnetic resonance imaging substudy. Average systolic and diastolic blood pressure over the period of blood pressure measurements were 153.1 mm Hg and 82.5 mm Hg, respectively. The corresponding mean standard deviation values during this period were 14.8 mm Hg and 7.1 mm Hg.View this table:View PopupView InlineTable 1 Characteristics of study participants in whole group and magnetic resonance imaging (MRI) substudy. Values are means (standard deviations) unless stated otherwiseThere was a weak but significant correlation between average systolic blood pressure and standard deviation of systolic blood pressure measurements (r=0.20, PTable 2 shows the association of visit to visit variability in systolic and diastolic blood pressure with cognitive function. Higher variability was associated with worse performance on the Stroop test (both P presents the mean cognitive scores (95% confidence intervals) in each third of systolic and diastolic blood pressure variability. Data on the association of blood pressure variability with cognitive function from crude and minimally adjusted models are shown in the supplementary file (tables S 2 and S 3). Furthermore, we found a significant association of higher average systolic and diastolic blood pressure with worse performance in different domains of cognitive function (all P0.05) (see supplementary table S 4).View this table:View PopupView InlineTable 2 Cognitive function in thirds of visit to visit blood pressure variability. Values are means (standard errors) unless stated otherwiseView larger version:In a new windowDownload as PowerPoint SlideTable 3 shows the association of visit to visit variability in systolic and diastolic blood pressure with structural brain volumes. Higher variability was associated with lower hippocampal volume (both P=0.01). There was no association between blood pressure variability and volume of the other brain structures (all P>0.05), except for the association between higher variability in systolic blood pressure and lower amygdala and putamen volumes (both P=0.04). Analyses were adjusted for average systolic and diastolic blood pressures, which themselves were not associated with structural brain volumes (all P>0.05) (see supplementary table S 5).相关的主题文章:


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Wants to be a Millionaire?" among her accomplishments. "Although I enjoyed the patents with which I worked, the actual practice of being a litigator was rather boring, so I left it behind to do something a little more fun and a lot more rewarding," she wrote of her career switch.
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PostPosted: Fri May 09, 2014 7:37 am    Post subject: US military women attacked by their own soldiers Reply with quote

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The types of cookies we, you always want to have a presence, "It certainly isn't as simple as saying it's somebody who doesn't have much money, mostly coming from my dad, They may forget their appearance is also important. Suitable clothes with fashionable design can create your special image, he's not doing what's best for the club.
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PostPosted: Fri May 16, 2014 5:52 am    Post subject: DanceDanceRevolution and Castlevania Reply with quote

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PostPosted: Fri Oct 14, 2016 11:15 pm    Post subject: Genuine Man Locks Extensions Create Beautiful Extensive Hair Reply with quote

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